Changes in Lipid Profile and Insulin Resistance in Morbidly Obese Patients Following Laparoscopic Total Gastric Vertical Plication
Journal of Minimally Invasive Surgical Sciences: 1 (1); 24-9
June 30, 2012
Article Type: Test Research
October 5, 2011
December 26, 2011
M. Changes in Lipid Profile and Insulin Resistance in Morbidly Obese Patients Following Laparoscopic Total Gastric Vertical Plication,
J Minim Invasive Surg Sci.
Online ahead of Print
Background: Obesity has emerged as one of the most serious public health concerns in the 21st century. The consequences of this chronic disorder are serious. Bariatric surgery has been shown to eliminate comorbid conditions associated with obesity. Currently it is considered to be the only successful, long-term therapy for morbidly obese subjects.\r\nObjectives: The aim of this study was to evaluate the e?ect of weight reduction following laparoscopic total gastric vertical plication on anthropometric indices, lipid pro?le and insulin resistance in morbidly obese patients.\r\nPatients and Methods: 15 severely obese patients aged 32.4 10 yr were enrolled in this prospective study. Body mass index (BMI), waist circumference, high-density lipoprotein cholesterol (HDL-c), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), triglycerides (TG), fasting glucose, fasting insulin and insulin sensitivity were measured before and 6 weeks after laparoscopic total gastric vertical plication (LTGVP). Insulin-sensitivity was estimated using the homeostasis model assessment of insulin-resistance (HOMA-IR).\r\nResults: Anthropometric indices decreased signi?cantly during the 6 week period after LTGVP. TG, LDL-c, fasting insulin, HOMA-IR and QUIKI also decreased but the changes in HDL-c, TC and fasting glucose were not signi?cant. At baseline, we found a direct correlation between weight and TC, weight and fasting glucose, waist to hip ratio and TG and a negative correlation between waist to hip ratios and HDL-c.\r\nLTGVP results in signi?cant weight loss among morbidly obese subjects, and following weight reduction, lipid pro?le and insulin resistance improved.
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