A Comparison Between Two Different Prophylactic Doses of Unfractionated Heparin for Deep Venous Thrombosis Prevention in Laparoscopic Bariatric Surgery

AUTHORS

Farzane Ebrahimifard 1 , Abdolreza Pazouki 2 , * , Masoud Solaymani Dodaran 1 , Mohammad Vaziri 1

1 Minimally Invasive Surgery Research Center, Rasool Akram Hospital, Tehran University of Medical Sciences. 2) Surgical Department, Shahid Beheshti University of Medical Sciences, IR Iran

2 Minimally Invasive Surgery Research Center, Rasool Akram Hospital, Tehran University of Medical Sciences, apazouki@yahoo.com, IR Iran

How to Cite: Ebrahimifard F, Pazouki A, Solaymani Dodaran M, Vaziri M. A Comparison Between Two Different Prophylactic Doses of Unfractionated Heparin for Deep Venous Thrombosis Prevention in Laparoscopic Bariatric Surgery, J Minim Invasive Surg Sci. Online ahead of Print ; 1(2):58-61. doi: 10.5812/jmiss.4991.

ARTICLE INFORMATION

Journal of Minimally Invasive Surgical Sciences: 1 (2); 58-61
Published Online: September 30, 2012
Article Type: Test Research
Received: March 27, 2012
Accepted: April 21, 2012
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Abstract

Background: Deep Venous Thrombosis (DVT) is a major risk of morbidity and mortality in morbid obese patients underwent bariatric surgery. There are some controversies in different kind of prophylactic strategies for DVT in laparoscopic bariatric surgeries. Unfractionated heparin (UFH) is an available and reversible anticoagulant used for DVT prophylaxis.

Objectives: This study aimed to compare clinical results of two different dosage regimes of unfractionated heparin for short term prophylaxis of DVT after bariatric surgery.

Patients and Methods: 139 patients with morbid obesity who underwent laparoscopic bariatric surgery (laparoscopic Roux-en-Y gastric bypass, sleeve gastrectomy, and laparoscopic gastric banding) were evaluated in two groups: group A received 5000 IU unfractionated heparin q12h and group B received the same dose but q8h ( preliminary dose received before induction of anesthesia followed by 2 or 3 times daily). All patients were evaluated by physical examination and Doppler ultra sound for DVT before and 10 days after surgery.

Results: There was no statistically significant difference between two groups in venous thrombosis. No thrombotic events were observed before and after operations. There were no heparin induced thrombocytopenia and no meaningful difference between two groups in postoperative bleeding.

Conclusions: This study showed that in combination with non-pharmacologic methods for prevention of thromboembolic events, both regimes of UFH prophylaxis had similar clinical effects.

Keywords

Heparin Obesity Bariatric Surgery Venous Thrombosis

© 2012, Journal of Minimally Invasive Surgical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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