Journal of Minimally Invasive Surgical Sciences

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A Prospective Randomized Trial to Study The Effect of Intraperitoneal Instillation of Ropivacaine in Postoperative Pain Reduction in Laparoscopic Cholecystectomy

Pankaj Shivhare 1 , Pankaj Dugg 1 , * , Harnam Singh 2 , Sushil Mittal 2 , Ashwani Kumar 2 and Anand Munghate 2
Authors Information
1 Department of Surgery, All India Institute of Medical Sciences, New Delhi, India
2 Department of General Surgery, Government Medical College, Patiala, India
Article information
  • Journal of Minimally Invasive Surgical Sciences: November 01, 2014, 3 (4); e18009
  • Published Online: September 17, 2014
  • Article Type: Research Article
  • Received: February 3, 2014
  • Revised: June 17, 2014
  • Accepted: July 15, 2014

To Cite: Shivhare P, Dugg P, Singh H, Mittal S, Kumar A, et al. A Prospective Randomized Trial to Study The Effect of Intraperitoneal Instillation of Ropivacaine in Postoperative Pain Reduction in Laparoscopic Cholecystectomy, J Minim Invasive Surg Sci. 2014 ; 3(4):e18009.

Copyright © 2014, Minimally Invasive Surgery Research Center and Mediterranean & Middle Eastern Endoscopic Surgery Association. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Shehadi WH. The biliary system through the ages. Int Surg. 1979; 64(6): 63-78[PubMed]
  • 2. Cuschieri A, Dubois F, Mouiel J, Mouret P, Becker H, Buess G, et al. The European experience with laparoscopic cholecystectomy. Am J Surg. 1991; 161(3): 385-7[PubMed]
  • 3. De U. Evolution of cholecystectomy: A tribute to Carl August Langenbuch. Ind J Surg. 2004; 66(2): 97-100
  • 4. A prospective analysis of 1518 laparoscopic cholecystectomies. The Southern Surgeons Club. N Engl J Med. 1991; 324(16): 1073-8[DOI][PubMed]
  • 5. Lahmann B, Adrales GL, Mastrangelo MJ, Jr, Schwartz RW. Laparoscopic cholecystectomy--technical considerations. Curr Surg. 2002; 59(1): 55-8[PubMed]
  • 6. Zucker KA, Bailey RW, Flowers J. Laparoscopic management of acute and chronic cholecystitis. Surg Clin North Am. 1992; 72(5): 1045-67[PubMed]
  • 7. Kum CK, Wong CW, Goh PM, Ti TK. Comparative study of pain level and analgesic requirement after laparoscopic and open cholecystectomy. Surg Laparosc Endosc. 1994; 4(2): 139-41[PubMed]
  • 8. Gupta R, Bogra J, Kothari N, Kohli M. Postoperative analgesia with intraperitoneal fentanyl and bupivacaine: a randomized control trial. Can J Med. 2010; 1(1): 1-11
  • 9. Joris J, Thiry E, Paris P, Weerts J, Lamy M. Pain after laparoscopic cholecystectomy: characteristics and effect of intraperitoneal bupivacaine. Anesth Analg. 1995; 81(2): 379-84[PubMed]
  • 10. Alexander JI, Hull MG. Abdominal pain after laparoscopy: the value of a gas drain. Br J Obstet Gynaecol. 1987; 94(3): 267-9[PubMed]
  • 11. Wills VL, Hunt DR. Pain after laparoscopic cholecystectomy. Br J Surg. 2000; 87(3): 273-84[DOI][PubMed]
  • 12. de Jong E, Field JA, Spinnler HE, Wijnberg JB, de Bont JA. Significant biogenesis of chlorinated aromatics by fungi in natural environments. Appl Environ Microbiol. 1994; 60(1): 264-70[PubMed]
  • 13. Dixon JB, Reuben Y, Halket C, O'Brien PE. Shoulder pain is a common problem following laparoscopic adjustable gastric band surgery. Obes Surg. 2005; 15(8): 1111-7[DOI][PubMed]
  • 14. Labaille T, Mazoit JX, Paqueron X, Franco D, Benhamou D. The clinical efficacy and pharmacokinetics of intraperitoneal ropivacaine for laparoscopic cholecystectomy. Anesth Analg. 2002; 94(1): 100-5[PubMed]
  • 15. Ingelmo PM, Bucciero M, Somaini M, Sahillioglu E, Garbagnati A, Charton A, et al. Intraperitoneal nebulization of ropivacaine for pain control after laparoscopic cholecystectomy: a double-blind, randomized, placebo-controlled trial. Br J Anaesth. 2013; 110(5): 800-6[DOI][PubMed]
  • 16. Gupta A, Thorn SE, Axelsson K, Larsson LG, Agren G, Holmstrom B, et al. Postoperative pain relief using intermittent injections of 0.5% ropivacaine through a catheter after laparoscopic cholecystectomy. Anesth Analg. 2002; 95(2): 450-6[PubMed]
  • 17. Trikoupi A, Papavramidis T, Kyurdzhieva E, Kesisoglou I, Vasilakos D. Intraperitoneal administration of ropivacaine during laparoscopic cholecystectomy: 14AP12–5. Eur J Anaesthesiol. 2010; 27(47): 222[DOI]
  • 18. Kucuk C, Kadiogullari N, Canoler O, Savli S. A placebo-controlled comparison of bupivacaine and ropivacaine instillation for preventing postoperative pain after laparoscopic cholecystectomy. Surg Today. 2007; 37(5): 396-400[DOI][PubMed]
  • 19. Memedov C, Menteş Ö, Şimşek A, Kece C, Yağci G, Harlak A, et al. Comparison of Analgesic Effects of Intraperitoneal Lornoxicam and Ropivacaine Administration in Laparoscopic Cholecystectomy. Trakya Univ Tip Fak Derg. 2010; 27(2): 142-9
  • 20. Pavlidis TE, Atmatzidis KS, Papaziogas BT, Makris JG, Lazaridis CN, Papaziogas TB. The effect of preincisional periportal infiltration with ropivacaine in pain relief after laparoscopic procedures: a prospective, randomized controlled trial. JSLS. 2003; 7(4): 305-10[PubMed]
  • 21. Park YH, Kang H, Woo YC, Park SG, Baek CW, Jung YH, et al. The effect of intraperitoneal ropivacaine on pain after laparoscopic colectomy: a prospective randomized controlled trial. J Surg Res. 2011; 171(1): 94-100[DOI][PubMed]
  • 22. Bisgaard T, Klarskov B, Kristiansen VB, Callesen T, Schulze S, Kehlet H, et al. Multi-regional local anesthetic infiltration during laparoscopic cholecystectomy in patients receiving prophylactic multi-modal analgesia: a randomized, double-blinded, placebo-controlled study. Anesth Analg. 1999; 89(4): 1017-24[PubMed]
  • 23. Rademaker BM, Kalkman CJ, Odoom JA, de Wit L, Ringers J. Intraperitoneal local anaesthetics after laparoscopic cholecystectomy: effects on postoperative pain, metabolic responses and lung function. Br J Anaesth. 1994; 72(3): 263-6[PubMed]
  • 24. Scheinin B, Kellokumpu I, Lindgren L, Haglund C, Rosenberg PH. Effect of intraperitoneal bupivacaine on pain after laparoscopic cholecystectomy. Acta Anaesthesiol Scand. 1995; 39(2): 195-8[PubMed]
  • 25. Cha SM, Kang H, Baek CW, Jung YH, Koo GH, Kim BG, et al. Peritrocal and intraperitoneal ropivacaine for laparoscopic cholecystectomy: a prospective, randomized, double-blind controlled trial. J Surg Res. 2012; 175(2): 251-8[DOI][PubMed]
  • 26. Callesen T, Hjort D, Mogensen T, Schouenborg L, Nielsen D, Reventlid H, et al. Combined field block and i.p. instillation of ropivacaine for pain management after laparoscopic sterilization. Br J Anaesth. 1999; 82(4): 586-90[PubMed]
  • 27. Tsai HW, Chen YJ, Ho CM, Hseu SS, Chao KC, Tsai SK, et al. Maneuvers to decrease laparoscopy-induced shoulder and upper abdominal pain: a randomized controlled study. Arch Surg. 2011; 146(12): 1360-6[DOI][PubMed]
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