Journal of Minimally Invasive Surgical Sciences

Published by: Kowsar

Liver Function Tests and Ultrasonography Findings in Iranian Morbid Obese Patients Undergoing Bariatric Surgery

Amir Hossein Faghihi 1 , Somayyeh Mokhber 2 , Arezou Hashemzadeh 2 , Pejman Mansouri 2 and Abdolreza Pazouki 1 , *
Authors Information
1 Associate Professor of Gastrohepatology, Assistant Professor of Minimally Invasive Surgery, Minimally Invasive Surgery Research Centre, Iran University of Medical Sciences, Tehran, Iran
2 Minimally Invasive Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Journal of Minimally Invasive Surgical Sciences: November 2016, 5 (4); e40979
  • Published Online: November 2, 2016
  • Article Type: Research Article
  • Received: August 1, 2016
  • Revised: October 30, 2016
  • Accepted: October 30, 2016
  • DOI: 10.17795/minsurgery.40979

To Cite: Faghihi A H, Mokhber S, Hashemzadeh A, Mansouri P, Pazouki A. Liver Function Tests and Ultrasonography Findings in Iranian Morbid Obese Patients Undergoing Bariatric Surgery, J Minim Invasive Surg Sci. 2016 ; 5(4):e40979. doi: 10.17795/minsurgery.40979.

Copyright © 2016, Minimally Invasive Surgery Research Center and Mediterranean & Middle Eastern Endoscopic Surgery Association. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2003; 289(1): 76-9[DOI][PubMed]
  • 2. Jia H, Lubetkin EI. Trends in quality-adjusted life-years lost contributed by smoking and obesity. Am J Prev Med. 2010; 38(2): 138-44[DOI][PubMed]
  • 3. Pazouki A, Mokhber S, Riazi S, Alibeigi P, Abdolhosseini M, Jesmi F. Assessment of Surgical Complications in Morbid Obese Patients, The Candidates for 2 Methods of Laparoscopic Bariatric Surgery (Laparoscopic Gastric Bypass, Laparoscopic Sleeve Gastrectomy). J Min Invasive Surg Sci. 2015; 4(4)[DOI]
  • 4. Chavez-Tapia NC, Tellez-Avila FI, Barrientos-Gutierrez T, Mendez-Sanchez N, Lizardi-Cervera J, Uribe M. Bariatric surgery for non-alcoholic steatohepatitis in obese patients. Cochrane Database Syst Rev. 2010; (1): 7340[DOI][PubMed]
  • 5. Suzuki K, Jayasena CN, Bloom SR. Obesity and appetite control. Exp Diabetes Res. 2012; 2012: 824305[DOI][PubMed]
  • 6. Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA. 2010; 303(3): 235-41[DOI][PubMed]
  • 7. Mirzazadeh A, Haghdoost AA, Bahrein F, Rezazadeh Kermani M. The Prevalence of Obesity in Iran in Recent Decade; a Systematic Review and Meta-Analysis Study. Iran J Public Health. 2008; 38(3): 1-11
  • 8. Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology. 2003; 37(5): 1202-19[DOI][PubMed]
  • 9. McCullough AJ. Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol. 2006; 40 Suppl 1: 17-29[DOI][PubMed]
  • 10. McCullough AJ. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis. 2004; 8(3): 521-33[DOI][PubMed]
  • 11. Chitturi S, Farrell GC. Etiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis. 2001; 21(1): 27-41[DOI][PubMed]
  • 12. Neuschwander-Tetri BA. Evolving pathophysiologic concepts in nonalcoholic steatohepatitis. Curr Gastroenterol Rep. 2002; 4(1): 31-6[DOI][PubMed]
  • 13. Lam BP, Younossi ZM. Treatment regimens for non-alcoholic fatty liver disease. Ann Hepatol. 2009; 8 Suppl 1: 51-9[PubMed]
  • 14. Rafiq N, Younossi ZM. Effects of weight loss on nonalcoholic fatty liver disease. Semin Liver Dis. 2008; 28(4): 427-33[DOI][PubMed]
  • 15. Sass DA, Chang P, Chopra KB. Nonalcoholic fatty liver disease: a clinical review. Dig Dis Sci. 2005; 50(1): 171-80[DOI][PubMed]
  • 16. Adams LA, Angulo P. Treatment of non-alcoholic fatty liver disease. Postgrad Med J. 2006; 82(967): 315-22[DOI][PubMed]
  • 17. Saadeh S, Younossi ZM, Remer EM, Gramlich T, Ong JP, Hurley M, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 2002; 123(3): 745-50[DOI][PubMed]
  • 18. Rashidi A, Mohammadpour-Ahranjani B, Vafa MR, Karandish M. Prevalence of obesity in Iran. Obes Rev. 2005; 6(3): 191-2[DOI][PubMed]
  • 19. Clark JM, Brancati FL, Diehl AM. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol. 2003; 98(5): 960-7[DOI][PubMed]
  • 20. Ioannou GN, Boyko EJ, Lee SP. The prevalence and predictors of elevated serum aminotransferase activity in the United States in 1999-2002. Am J Gastroenterol. 2006; 101(1): 76-82[DOI][PubMed]
  • 21. Nomura F, Ohnishi K, Satomura Y, Ohtsuki T, Fukunaga K, Honda M, et al. Liver function in moderate obesity--study in 534 moderately obese subjects among 4613 male company employees. Int J Obes. 1986; 10(5): 349-54[PubMed]
  • 22. Albert S, Borovicka J, Thurnheer M, Lange J, Meyenberger C. [Pre- and postoperative transaminase changes within the scope of gastric banding in morbid obesity]. Praxis (Bern 1994). 2001; 90(35): 1459-64[PubMed]
  • 23. Silverman EM, Sapala JA, Appelman HD. Regression of hepatic steatosis in morbidly obese persons after gastric bypass. Am J Clin Pathol. 1995; 104(1): 23-31[DOI][PubMed]
  • 24. Akwaa AA. . Pattern of Liver Function Tests in Morbidly Obese Saudi Patients Undegoing Bariatric Surgery. Saudi J Gastroenterol. 2011; 17(4): 252-5
  • 25. Wolf AM, Busch B, Kuhlmann HW, Beisiegel U. Histological changes in the liver of morbidly obese patients: correlation with metabolic parameters. Obes Surg. 2005; 15(2): 228-37[DOI][PubMed]
  • 26. Guzman-Aroca F, Frutos-Bernal MD, Bas A, Lujan-Mompean JA, Reus M, Berna-Serna Jde D, et al. Detection of non-alcoholic steatohepatitis in patients with morbid obesity before bariatric surgery: preliminary evaluation with acoustic radiation force impulse imaging. Eur Radiol. 2012; 22(11): 2525-32[DOI][PubMed]
  • 27. Boza C, Riquelme A, Ibanez L, Duarte I, Norero E, Viviani P, et al. Predictors of nonalcoholic steatohepatitis (NASH) in obese patients undergoing gastric bypass. Obes Surg. 2005; 15(8): 1148-53[DOI][PubMed]
  • 28. Welsh JA, Karpen S, Vos MB. Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988-1994 to 2007-2010. J Pediatr. 2013; 162(3): 496-500 e1[DOI][PubMed]
  • 29. Younossi ZM, Stepanova M, Afendy M, Fang Y, Younossi Y, Mir H, et al. Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008. Clin Gastroenterol Hepatol. 2011; 9(6): 524-30[DOI][PubMed]
  • 30. Wang Z, Xu M, Hu Z, Shrestha UK. Prevalence of nonalcoholic fatty liver disease and its metabolic risk factors in women of different ages and body mass index. Menopause. 2015; 22(6): 667-73[DOI][PubMed]
  • 31. Eguchi Y, Hyogo H, Ono M, Mizuta T, Ono N, Fujimoto K, et al. Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study. J Gastroenterol. 2012; 47(5): 586-95[DOI][PubMed]
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